through Reinforcement of Biomedical Science and Technology
Partner 1
InstitInstitute of Medical Research (IMR)
founded 60 years ago by the Serbian Academy of Science, is
an organization which conducts fundamental and applied research in different
fields of biomedicine. Main goal is application and dissemination of knowledge
through publication, education and international co-operation. Today, IMR
comprises more than 45 researchers (medical doctors, biologists, molecular
biologists, chemists, pharmacists, biochemists etc.) organized in eight research
units - laboratories. Having in mind the proposed topics of the project the
investigators from the following laboratories will be engaged: Laboratory for
Hematology, Laboratory for immunohistochemistry and electron microscopy
(including their Consultation service). Main scientific topics of above
laboratories are:
Hematology ( Participant 1) >
- investigations in vitro and in vivo of
hematopoietic cells (stem, progenitors, precursors and mature, functional),
regulators and regulatory mechanisms of cytokines and growth factors
(erythropoietin, interleukins, CSF’s and others) in the animal experimental
models - hereditary anemic animals, anemic and policythemic animals, animals
with aplasia, immunosuppression and with induced inflammation (sterile,
infectious), and malignances and patients with hematological disorders; the
effects of cytostatics, irradiation, immunomodulators and other agents on
hematopoiesis; ex vivo propagation, preparation and quantification of
hematopoietic stem cells from peripheral blood, bone marrow and umbilical blood
for autologous and heterologous transplantation in humans; cryopreservation of
hematopoietic cells; establishment of animal experimental models and protocols
design for the observation of the new drug effects over time.
Cytology and pathohystology (Participant 2) -
expertise in all aspects of diagnostic/research immunohistopathology, especially in
histopathology of both neuro-endocrine tumors and tumors of the gastrointestinal
tract. Investigations in experimental areas as follows: 1. ontogeny,
differentiation and growth of the neuroendocrine system; 2. activation/cell
cycle markers; 3. apoptosis and their control mechanism; 4. cytosceletal
proteins; 5. extracellular matrix; 6. hormone receptors; 7.
hormones/neuropeptides-alymentary tract; 8. B/T/natural killer cell associated
markers; 9. mesenchymal markers; 10. muscle cell markers; 11. neuronal and
neuroepithelial cell markers; 12. endothelial cells; 13. onco and oncofetal
proteins. In addition, there is interest for ultrastructural investigations
during both ontogenesis and oncogenesis.
CO-ORDINATOR:
Sc.D.
Pavle MILENKOVI"style4">C, Professor of Pathophysiology and
Professor of Research, IMR (1)
M.D.
School of Medicine-University of Belgrade, (1967)
M.Sc., in Medicine, School of Medicine-University of Belgrade, (1974)
M.D. Sc.D., in Medicine, Doctor of Science degree (equiv. to
Ph.D.), School of Medicine-University of Belgrade, (1979)
Present position: Head of Laboratory for Hematology; Head of Department of Pathophysiology at the Faculty of Stomathology; Editor in Chief of Bulletin of Hematology (Yugoslav Society of Hematology); Editorial Board, Archives of Oncology; Federal expert - pathophysiology, immunology; Member of Academy of Medical Sciences - Serbian Medical Assotiation; Member of National Council for Scientific and Technological Development; President of the Board of Directors IMGGE.
Research interest: experimental and applied hematology, pathophysiology
Publications: 250 (citation index
245)
Vera TODOROVIĆ, M.D., Sc.D., Professor of Pathophysiology and
Professor of Research, IMR (2)
M.D.
School of Medicine-University of Belgrade, (1978)
M.Sc., in Medicine, School of Medicine-University of Belgrade, (1984)
M.D. Sc.D., in Medicine, Doctor of Science degree (equiv. to
Ph.D.), School of Medicine-University of Belgrade, (1991)
Present position: Head of Laboratory for Pathohistology and Cytology;
President of Board of Directors, IMR; Vicepresident of the Scientific Committee,
IMR; Federal expert clinical pathology and cytology
Research interest: Neuroendocrine pathology, gastrointestinal pathology
Publications: 374 (citation index 100)
Gordana JOVCIC, Ph.D., Professor of Research, IMR (1)
B.Sc. in Chemistry, Faculty of Natural Sciences and Mathematics, University of
Belgrade (1972)
M.Sc. in Molecular Biology, Center for Multidisciplinary Study, University of Belgrade
(1980)
Ph.D. in Biology, Faculty of Biology, University of Belgrade (1991)
Present position: IMR Director, IMR; Laboratory for
Hematology
Research interest: experimental and applied hematology, growth factors
Publications: 164 (citation index 118)
Vesna KOKO, PhD in Biology (2)
Diana BUGARSKI, PhD in Medicine (1)
Mirela BUDEC, PhD in Medicine (2)
PARTNER 2
Institute for Molecular Genetics and Genetic Engineering
(IMGGE), Belgrade
Laboratory for molecular hematology (Participant 3)
Main topics: molecular diagnosis and monitoring in the management of
leukemia’s; pharmacogenetics; molecular genetics of thalassemia syndromes;
molecular genetics of phenilketonuria
Sonja PAVLOVIC, PhD, IMGGE (3)
BSc in Molecular Biology and Physiology, University of Belgrade, 1992.
MSc in Molecular Biology, University of Belgrade, 1996.
PhD in Molecular Biology, University of Belgrade, 2001.
Present position: Head of the Laboratory of Molecular Hematology, IMGGE
Research interest: molecular diagnostics of leukemias, pharmacogenetics,
molecular genetics of
thalassemias, phenylketonuria, inflamatory bowel disease
Publications: 50
Tatjana KOSTIC, PhD (3)
PARTNER 3
Institute for Application of Nuclear Energy (INEP), Belgrade
Laboratory for pathophysiology of thyroid (Participant 4)
Main topics: identification of thyroid gland specific tissue or secreted
markers of malignant transformation solation and characterization of animal
lectins (galectins, c-type lectins); investigation of the microheterogeneity of
thyroid proteins and hormones; development of quantitation assays for
heterogenous analytes;
Dubravka CVEJIC, Ph.D.,
Senior Research Fellow INEP (4)
B.Sc in Bilogy, Faculty of Natural Sciences and Mathematics, University of
Belgrade (1980)
M.S. in Biology, Faculty of Natural Sciences and Mathematics, University of
Belgrade (1985)
Ph.D. in Biology, Faculty of Biology, University of Belgrade (1995)
Publications: 38
Svetlana SAVIN, PhD (4)
Laboratory for metabolism-IGF/IGFBP system ( Participant 5)
Main topics: metabolic disseases and secondary metabolic disorders, in
particular, IGFs and IGFBPs.
Olgica NEDIC, Ph.D.,
Senior Research Fellow ( 5)
B.Sc in Chemistry, , Faculty of Natural Sciences and Mathematics, University of
Belgrade (1985)
M.S. in Biochemistry, Faculty of Natural Sciences and Mathematics, University of
Belgrade (1988)
Ph.D. in Biochemistry, Faculty of Chemistry, University of Belgrade (1994)
Publications: 57
Ivona BARICEVIC, PhD (5)
Laboratory for glycoprotein markers in oncology (Participant
6)
Main topics: Investigation of the microheterogeneity of glycoproteins
tumor markers; development of solid phase binding assays for heterogenous
analytes (IRMA, ELISA, ELBA)
Ljiljana HAJDUKOVIĆ, PhD (6)
B.Sc in Pharmacy, , Faculty of Pharmacy, University of Belgrade (1982)
M.S. in Biochemistry, Faculty of Natural Sciences and Mathematics, University of
Belgrade (1990)
Ph.D. in Biochemistry, Faculty of Chemistry, University of Belgrade (1999)
Publications: 23
Ljiljana VICOVAC PANIĆ, PhD (6)